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Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Epileptiform seizure after sertraline treatment in an adolescent experiencing obsessive-compulsive disorder and presenting a rare pharmacogenetic status. Rev Med Suisse ;2: Dialogues Clin Neurosci ;7: Psychotropic Drug Directory Healthcomm UK Ltd, All-cause treatment discontinuation in schizophrenia during treatment with olanzapine relative to other antipsychotics: Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states.

Nord J Psychiatry ; Cytochrome P 3A4 and 2C8 are involved in zopiclone metabolism. Ziprasidone metabolism, aldehyde oxidase, and clinical implications. Drug metabolism and pharmacokinetics. P phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug Metab Pharmacokinet ; Therapeutic drug monitoring of psychotropic drugs. J Neurol Sci ; Olanzapine plasma concentration, average daily dose, and interaction with co-medication in schizophrenic patients.

Plasma amisulpride levels in schizophrenia or schizoaffective disorder. Therapeutisches Drug-Monitoring von Psychopharmaka in der Schwangerschaft. J Neurol Neurochir Psychiatr ; Olanzapine in subjects with and without renal failure data on file. Lilly Laboratory for Clinical Research. Eli Lilly and Co. Berry D, Millington C. Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: A comparison of serum prolactin concentrations after administration of paliperidone extended—release and risperidone tablets in patients with schizophrenia.

Imipramine dose in relation to therapeutic plasma level: Relationship between clinical effects, serum drug concentration and serotonin uptake inhibition in depressed patients treated with citalopram. A double-blind comparison of three dose levels. High dosage haloperidol therapy in chronic schizophrenic patients: Clinical pharmacokinetics of gabapentin. Population pharmacokinetics of pregabalin in healthy subjects and patients with chronic pain or partial seizures. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin.

Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling. Eur J Pharm Sci ; Effect of psychotropic medication on the in vitro metabolism of buprenorphine in human cDNA-expressed cytochrome P enzymes. Systemic absorption and abuse liability of snorted flunitrazepam. Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients.

Torsade de pointes after pipamperone intoxication. Pharm World Sci ; Pharmacokinetics of parenteral and oral melperone in man. Am J Emerg Med ; A fatal case of venlafaxine overdose. J Med Toxicol ;4: Cytochrome P enzymes contributing to demethylation of maprotiline in man. Clinical experience with carbamazepine overdose: Therapeutic drug monitoring in Epileptologie und Psychiatrie [Therapeutic drug monitoring in epileptology and psychiatry].

The metabolic fate of amitriptyline, nortriptyline and amitriptyline oxide in man. Prediction and evaluation criteria in perazine therapy of acute schizophrenics pharmacokinetic data. Breyer-Pfaff U, Nill K. Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol. J Pharm Pharmacol ; The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment. Clin Pharmacol Ther ; Drug-metabolizing enzymes and therapeutic drug monitoring in psychiatry.

Steady-state levels of imipramine and its metabolites: Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. A double-blind, fixed blood-level study comparing mirtazapine with imipramine in depressed in-patients. Literature review using a TDM appropriateness rating scale. Ther Drug Monit ;in press. The schizophrenia PORT psychopharmacological treatment recommendations and summary statements.

Greater toxicity in overdose of dothiepin than of other tricyclic antidepressants. Therapeutic drug monitoring of antidepressants — cost implications and relevance to clinical practice. Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. Caccia S, Garattini S. Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites.

New atypical antipsychotics for schizophrenia: Drug Des Devel Ther ;4: Pharmacokinetic and pharmacodynamic profile. A new oral formulation of tiapride drops: Clin Drug Investig ; Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindone and norsertindole, in human plasma. J Chromatography B ; Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea-pigs.

Enantioselective analysis of citalopram and metabolites in adolescents. Quetiapine and drug interactions: J Clin Psychiatry ; Castberg I, Spigset O. Prescribing pattern and use of therapeutic drug monitoring of psychotropic medication in a psychiatric high-security unit. Validation of chromatographic methods in biomedical analysis.

Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: Pharmacokinetics and sedative effects in healthy subjects and subjects with impaired liver function after continuous infusion of clomethiazole. Single dose kinetics of thioridazine and its two psychoactive metabolites in healthy humans: J Pharm Sci ; Population pharmacokinetics of lamotrigine. Optimizing early prediction for antipsychotic response in schizophrenia.

Plasma concentrations of buprenorphine 24 to 72 hours after dosing. Drug Alcohol Depend ; Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: Chem Res Toxicol ; A computer-based intervention for improving the appropriateness of antiepileptic drug level monitoring. Am J Clin Pathol ; Pharmacokinetics of haloperidol in psychotic patients. Comparison of pharmacokinetic profiles of brand-name and generic formulations of citalopram and venlafaxine: Assessment of the prescription of antidepressant drungs in elderly nursing home patients.

Therapeutic drug monitoring of ziprasidone in a clinical treatment setting. The use of a side effect as a qualitative indicator of plasma chlorpromazine levels. Single- vs multiple—dose pharmacokinetics of clozapine in psychiatric patients. Expert Opin Drug Metab Toxicol ;6: Pharmacokinetics and pharmacodynamics of multiple sublingual buprenorphine tablets in dose—escalation trials.

J Clin Pharmacol ; Paliperidone palmitate — review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication. Int J Clin Pract ; Standards of lithium monitoring in mental health trusts in the UK. Therapeutic drug monitoring in Italian psychiatry. Plasma level monitoring of antipsychotic drugs. Coppen A, Kopera H. Workshop on the clinical pharmacology and efficacy of mianserin. Br J Clin Pharmacol ;5: Early prediction of antipsychotic response in schizophrenia. Plasma clozapine and norclozapine in patients prescribed different brands of clozapine Clozaril, Denzapine, and Zaponex.

Plasma clozapine, norclozapine, and the clozapine: Pharmacokinetics of single-dose reboxetine in volunteers with renal insufficiency. A comparative double-blind controlled study of trimipramine and amitriptyline in major depression: J Clin Psychopharmacol ;7: Interindividual variability in hepatic drug glucuronidation: Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog Neuropsychopharmacol Biol Psychiatry ; ABCB1 and cytochrome P genotypes and phenotypes: Pharmacokinetic rationale for the rivastigmine patch.

Neurology ;69 Suppl 1: Active metabolites of neuroleptic drugs: Ther Drug Monit ;4: Pharmacokinetics and relative bioavailability of levomepromazine after repeated administration of tablets and syrup. Long-term therapeutic drug monitoring of risperidone and olanzapine identifies altered Steady-state pharmacokinetics: Steady-state clinical pharmacokinetics of bupropion extended-release in youths. Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: Monitoring of tricyclic antidepressant therapy.

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Adv Drug Deliv Rev ; Glucuronidation enzymes, genes and psychiatry. Int J Neuropsychopharmacol ;6: Incorporating pharmacogenetics into clinical practice: Current issues in clinical implementation. CNS Spectr ;11 Suppl 3: The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects talking drugs metabolized by CYP2D6 or CYP2C Practical guidelines for the use of new generation antipsychotic drugs except clozapine in adult individuals with intellectual disabilities.

Res Dev Disabil ; The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. The pharmacokinetics of paliperidone versus risperidone. Erythromycin increases plasma concentrations of alpha-dihydroergocryptine in humans. Single and multiple oral dose fluvoxamine kinetics in young and elderly subjects. Lorazepam concentrations, pharmacokinetics and pharmacodynamics in a cohort of mechanically ventilated ICU patients. Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure.

Med Klin Munich ; Severe adverse drug reactions of antidepressants: Del Dotto P, Bonuccelli U. Clinical pharmacokinetics of cabergoline. Therapeutic drug monitoring in pregnant and postpartum women: Can Fam Physician ; Identification and characterization of human cytochrome P isoforms interacting with pimozide. Doxepin and its metabolites in plasma and cerebrospinal fluid in depressed patients. Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats. Int J Neuropsychopharmacol ;2: Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: J Psychopharmacol ;20 Suppl: Plasma clozapine concentration coefficients of variation in a long-term study.

Estimating the size of the effects of co-medications on plasma clozapine concentrations using a model that controls for clozapine doses and confounding variables. Multiple-dose clinical pharmacology of the catechol-O-methyl-transferase inhibitor tolcapone in elderly subjects. Pharmacokinetics of a newly identified active metabolite of buspirone after administration of buspirone over its therapeutic dose range.

Single-dose pharmacokinetics and effect of food on the bioavailability of topiramate, a novel antiepileptic drug. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Population pharmacokinetics of extended—release injectable naltrexone XR-NTX in patients with alcohol dependence. J Stud Alcohol Drugs ; ABC transporters and cytochromes P in the human central nervous system: Pharmacokinetic interpretation of data gathered during therapeutic drug monitoring.

Lithium monitoring before and after the distribution of clinical practice guidelines. Acta Psychiatr Scand ; Eap CB, Baumann P. Analytical methods for the quantitative determination of selective serotonin reuptake inhibitors for therapeutic drug monitoring purposes in patients. J Chromatogr B Biomed Appl ; High interindividual variability of methadone enantiomer blood levels to dose ratios. Arch Gen Psychiatry ; Interindividual variability of the clinical pharmacokinetics of methadone: Replacement of R—methadone by a double dose of R,S -methadone in addicts: Determination of trimipramine and its demethylated and hydroxylated metabolites in plasma by gas chromatography-mass spectrometry.

Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine. Pharmacogenomics and individualized drug therapy. Annu Rev Med ; Clinical pharmacokinetic studies of perphenazine. Br J Clin Pharmacol ;3: Comparative pharmacokinetics and pharmacodynamics of lorazepam, alprazolam and diazepam.

Effects of smoking on fluphenazine clearance in psychiatric inpatients. The bioavailability of oral and parenteral chlorimipramine Anafranil. Faber MS, Fuhr U. Time response of cytochrome P 1A2 activity on cessation of heavy smoking. Assessment of CYP1A2 activity in clinical practice: Basic Clin Pharmacol Toxicol ; Multiple—does pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers. Elimination kinetics of disulfiram in alcoholics after single and repeated doses. World J Biol Psychiatry ;6: World J Biol Psychiatry ;7: Fatal intoxication with milnacipran.

J Forensic Leg Med ; Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study. Drug-drug interactions mediated through P-glycoprotein: Pharmacokinetic profiles of extended release quetiapine fumarate compared with quetiapine immediate release. Paroxetine pharmacokinetics in depressed children and adolescents.

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Predicting haloperidol occupancy of central dopamine D2 receptors from plasma levels. Developing an analytical toxicology service: Fleming J, Chetty M. Therapeutic monitoring of valproate in psychiatry: O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: Bromazepam and lorazepam in generalized anxiety: Food and Drug Administration. Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation.

An update of evidence-based treatment of bipolar depression: Curr Opin Psychiatry ; The influence of smoking on the serum level of duloxetine. Clinical outcome after trimipramine in patients with delusional depression — a pilot study. Pharmacokinetics and pharmacodynamics of oral diazepam: Plasma moclobemide and metabolites: Eur J Pharmacol ; Effects of genetic polymorphism of cytochrome P enzymes on the pharmacokinetics of benzodiazepines.

J Clin Pharm Ther ; Steady-state serum concentrations of imipramine, its main metabolites and clinical response in primary enuresis. Effects of itraconazole on the Steady-state plasma concentrations of bromperidol and reduced bromperidol in schizophrenic patients. Response to Maprotiline treatment in depressive patients, relationship to urinary MHPG excretion, and plasma drug level.

Therapeutic drug monitoring of clozapine in relapse prevention: A review of the current guidelines for depression treatment. Tiagabine in clinical practice. Epilepsia ;42 Suppl 3: Therapeutic drug monitoring of quetiapine in adolescents with psychotic disorders. Relationship between clinical effects of fluvoxamine and the Steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino acid in Japanese depressed patients. Potential role of cerebral cytochrome P in clinical pharmacokinetics: Clomipramine concentration as a predictor of delayed response: Therapeutic drug monitoring of olanzapine: Time course of clinical response to venlafaxine: Time course of response to paroxetine: Paroxetine serum concentrations in depressed patients and response to treatment.

Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol ; Clinical implications of imipramine plasma levels for depressive illness. Tricyclic antidepressants, blood level measurements and clinical outcome: Am J Psychiat ; Controversies in blood-level monitoring: Epilepsia ;41 Suppl 8: Psychopharmacological treatment for very young children: Brain concentrations of tricyclic antidepressants: Single—dose kinetics and relationship to plasma concentrations in chronically dosed rats.

Postmortem forensic toxicology of selective serotonin reuptake inhibitors: J Forensic Sci ; J Am Geriatr Soc ; A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence. Bupropion slow-release response in depression: Evidence-based guidelines for treating bipolar disorder: Clinical pharmacology and therapeutic monitoring. Relationship between mirtazapine dose, plasma concentration, response, and side effects in clinical practice. Impact of polymorphisms of cytochrome-P isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting.

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo. Pharmocokinetics and pharmacodynamics of single—dose triazolam: A large-sample study of diazepam pharmacokinetics. Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo. Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans. Kinetics and dynamics of lorazepam during and after continuous intravenous infusion. Crit Care Med ; Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.

Determination of citalopram and escitalopram together with their active main metabolites desmethyl es- citalopram in human serum by column-switching high performance liquid chromatography HPLC and spectrophotometric detection. Pharmacokinetic and pharmacodynamic studies following the intravenous and oral administration of the antiparkinsonian drug biperiden to normal subjects. The AMSP drug safety program: Pharmacopsychiatry ;37 Suppl 1: Mechanism of new antipsychotic medications.

Occupancy is not just antagonism. Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: Therpaeutic drug concentrations of antidepressants and antipsychotics: Guidance from PET imaging. Nat Rev Drug Discov ;8: World J Biol Psychiatry ; Am J Geriatr Pharmacother ;4: Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations.

Can J Neurol Sci ; ABCB1 polymorphisms influence Steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety. Guidelines for lithium monitoring: Therapeutic monitoring of sertraline. Pharmacokinetic and pharmacodynamic characterization of OROS and immediate-release amitriptyline. Department of Health, Education, and Welfare; Clinical guidelines and family advice. Neuropsychiatr Dis Treat ;6: Hallett C, Dean BC.

Curr Med Res Opin ;8: Acamprosate determinations in plasma and cerebrospinal fluid after multiple dosing measured by liquid chromatography—mass spectroscopy: The effects of acomprosate on alcohol—cue reactivity and alcohol priming in dependent patients: The meaning and use of the area under a receiver operating characteristic ROC curve.

Felbamate levels in patients with epilepsy. The role of cytochrome P 2D6 in the metabolism of moclobemide. Automated determination of trimipramine and N-desmethyl—trimipramine in human plasma or serum by HPLC with on—line solid phase extraction. J Liq Chromatogr ; Automated determination of paroxetine and its main metabolite by column switching and on—line high—performance liquid chromatography. Column switching and high—performance liquid chromatography in the analysis of amitriptyline, nortriptyline and hydroxylated metabolites in human plasma or serum.

Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. Automated determination of reboxetine by high-performance liquid chromatography with column-switching and ultraviolet detection. Automated determination of fluvoxamine in plasma by column-switching high-performance liquid chromatography. Quetiapine serum concentrations in psychiatric patients: Pharmacotherapy of disruptive behavior in mentally retarded subjects: A review of the current literature.

Dev Disabil Res Rev ; Haymond J, Ensom MH. Does valproic acid warrant therapeutic drug monitoring in bipolar affective disorder? Atten Defic Hyperact Disord ;1: The serotonin syndrome scale: Eur Arch Psychiatry Clin Neuroci ; Pharmacokinetics of entacapone, a peripherally acting catechol—O—methyltransferase inhibitor, in man.

A study using a stable isotope techique. Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM service. Impact of the CYP2D6 genotype on Steady-state serum concentrations of aripiprazole and dehydroaripiprazole.

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Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans. Clozapine and norclozapine concentrations in serum and plasma samples from schizophrenic patients. Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P 2B6 in human liver microsomes. Clinical utility of drug measurement and pharmacokinetics — therapeutic drug monitoring in psychiatry. Therapeutic drug monitoring in neuropharmacology: Therapeutisches Drug—Monitoring in der Psychiatrie. Therapeutic monitoring of new antipsychotic drugs. Pharmacokinetics of selective serotonin reuptake inhibitors.

Milnacipran plasma levels and antidepressant response in Japanese major depressive patients. Fatal cardiotoxicity induced by venlafaxine overdosage. Clin Toxicol Phila ; Clinical monitoring guidelines for neuroleptic and antidepressant drugs. Central State Hospital, Milledgeville, Georgia. Quetiapine in adolescents with non-affective psychotic disorders: Clin Exp Neurol ; Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function.

Ann Intern Med ; Plasma levels of maprotiline and zimelidine and their relationship to clinical response in depressed patients. Ther Drug Monit ;8: Steady-state plasma concentrations of midazolam in critically ill infants and children. J Cardiovasc Pharmacol ; Plasma concentrations of dothiepin and its metabolites are not correlated with clinical efficacy in major depressive illness. The utilization of antidepressants—a key issue in the prevention of suicide: Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m—chlorophenylpiperazine.

Iwersen S, Schmoldt A. One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites. J Anal Toxicol ; Maintenance therapy with zuclopenthixol decanoate: Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics. Pharmacokinetics and pharmacodynamics of clozapine. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.

ABCB1 and cytochrome P polymorphisms: Therapeutic drug monitoring and pharmacogenetic rests as tools in pharmacovigilance. Bupropion for major depressive disorder: The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol. Pharmacokinetic interaction between efavirenz and carbamazepine after multiple—dose administration in healthy subjects. Clinical toxicology of citalopram after acute intoxication with the sole drug or in combination with other drugs: The effect of reporting methods for dosing times on the estimation of pharmacokinetic parameters of escitalopram.

Pharmacokinetics of brotizolam in healthy subjects following intravenous and oral administration. Br J Clin Pharmacol ;16 Suppl 2: Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monitor ; Johannessen SI, Tomson T. Pharmacokinetic variability of newer antiepileptic drugs: A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites.

Acta Psychiatr Scand Suppl ; Relationship between drug exposure and the efficacy and safety of bupropion sustained release for smoking cessation.

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    Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes-focus on venlafaxine and O-desmethylvenlafaxine. The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. J Clin Psychiatry ;12 Suppl: Biopharmaceutical and clinical pharmacokinetic profile of bromazepam. J Pharmacokinet Biopharm ;4: Plasma concentrations of fluvoxamine and maprotiline in major depression: Effects of cigarette smoking and cytochrome P 2D6 genotype on fluvoxamine concentration in plasma of Japanese patients. Biol Pharm Bull ; Impact of antidepressant drug adherence on comorbid medication use and resource utilization.

    Arch Intern Med ; Kaufman E, Lamster IB. The diagnostic applications of saliva — a review. Crit Rev Oral Biol Med ; Kaye CM, Nicholls B. Clinical pharmacokinetics of ropinirole. Clinical value of early partial symptomatic improvement in the prediction of response and remission during short-term treatment trials in subjects with bipolar I or II depression. J Affect Disord ; Human liver carbamazepine metabolism. Drug metabolism and ageing. CYP2D6 phenotype prediction from genotype: Pharmacogenetics of antidepressants and antipsychotics: Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: J Chromatogr B ; Therapeutic and toxic concentrations of mirtazapine.

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    How high can we go with phenytoin? Krska J, Corner DA. Serum drug level monitoring in affective disorders. Postmortem redistribution of the enantiomers of citalopram and its metabolites: J Analyt Toxicol ; Relationship of plasma buprenorphine and norbuprenorphine to withdrawal symptoms during dose induction, maintenance and withdrawal from sublingual buprenorphine. Kuss HJ, Feistenauer E.

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    Clinical pharmacology and therapeutic drug monitoring of zonisamide. Zonisamide monotherapy with once—daily dosing in children with cryptogenic localization—related epilepsies: Seizure ;13 Suppl 1: Miura M, Ohkubo T. Identification of human cytochrome P enzymes involved in the major metabolic pathway of fluvoxamine.

    Pharmacokinetic variability of aripiprazole and the active metabolite dehydroaripiprazone in psychiatric patients. Relationsship between mianserin plasma levels and antidepressant effect in a double-blind trial comparing a single night-time and divided daily dose regimens. The in vivo response of novel buprenorphine metabolites, M1 and M3, to antiretroviral inducers and inhibitors of buprenorphine metabolism. Lamotrigine and therapeutic drug monitoring: Long—term follow—up using a higher target range for lamotrigine monitoring. Psychiatric pharmacogenomic testing in clinical practice.

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